候选组织

（按排名）

桂林医学院

广西师范大学

博瑞生物医药（苏州）股份有限公司

桂林师范高等专科学校

完成人姓名、职称、从事专业（按提名排序）

张业，教授，药物化学

马献力，教授，药物化学

陈振锋，教授，药物化学

黄日镇，讲师，药物化学

黄仰青，研究员，制药工程

黄晓超，讲师，化学生物学

韦健华，讲师，药物化学

丁海峰，高级工程师，生物制药

方毅林，副教授，药物化学

邹碧群，教授，化学生物学

主要成果名称

（按排序）

1. Gui-Bin Liang, Yan-Cheng Yu, Jian-Hua Wei, Wen-Bin Kuang, Zhen-Feng Chen, Ye Zhang. Design, synthesis and biological evaluation of naphthalenebenzimidizole platinum (II) complexes as potential antitumor agents[J]. Eur. J. Med. Chem., 2020, 188: 112033.

2. Xiao-Chao Huang, Meng Wang, Qing-Cong You, Jing Kong, Hai-Jiang Zhang, Chun-Hao Yu, Yan-Ming Wang, Heng-Shan Wang, Ri-Zhen Huang. Synthesis, mechanisms of action, and toxicity of novel aminophosphonates derivatives conjugated irinotecan in vitro and in vivo as potent antitumor agents[J]. Eur. J. Med. Chem., 2020, 189: 112067.

3. Wen-Bin Kuang, Ri-Zhen Huang, Jiao-Lan Qin, Xing Lu, Qi-Pin Qin, Bi-Qun Zou, Zhen-Feng Chen, Hong Liang, Ye Zhang. Design, synthesis and pharmacological evaluation of new 3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents[J]. Eur. J. Med. Chem., 2018, 157: 139‒150.

4. Yang-Qing Huang, Jian-Dong Yuan, Hai-Feng Ding, Yun-Song Song, Gang Qian, Jia-Li Wang, Min Ji, Ye Zhang. Design, synthesis and pharmacological evaluation of a novel PEG-cRGD-conjugated irinotecan derivative as potential antitumor agent[J]. Eur. J. Med. Chem., 2018, 158: 82‒90.

5. Yan-Cheng Yu, Wen-Bin Kuang, Ri-Zhen Huang, Yi-Lin Fang, Ye Zhang, Zhen-Feng Chen, Xian-Li Ma. Design, synthesis andpharmacological evaluation of new 2-oxoquinoline derivatives containing α-aminophosphonates as potential antitumor agents[J]. MedChemComm, 2017, 8: 1158‒1172.

6. Shi-Xian Hua, Ri-Zhen Huang, Man-Yi Ye, Ying-Ming Pan, Gui-Yang Yao, Ye Zhang, Heng-Shan Wang, Design, synthesis and in vitro evaluation of novel ursolic acid derivatives as potential anticancer agents[J], European Journal of Medicinal Chemistry, 2015, 95, 435-452.

7. Man-Yi Ye, Gui-Yang Yao, Ying-Ming Pan, Zhi-Xin Liao, Ye Zhang, Heng-Shan Wang, Synthesis and antitumor activities of novel a-aminophosphonate derivatives containing an alizarin moiety[J], European Journal of Medicinal Chemistry, 2014, 83, 116-128.

8. Jian-Fei Li, Ri-Zhen Huang, Gui-Yang Yao, Man-Yi Ye, Heng-Shan Wang, Ying-Ming Pan, Jing-Teng Xiao. Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents[J]. Eur. J. Med. Chem., 2014, 86: 175‒188.